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Antibody Product Overview
| ELK.No | EA321 |
| Product name | CD10 Rabbit pAb |
| Reactivity | Human, Rat, Mouse |
| Applications | IHC |
| Other name | CALLA, Enkephalinase,MME,NEP, Neutral endopeptidase antibody |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4311 |
| Human Swiss-Prot | P08473 |
| Source | Rabbit |
| Isotype | IgG |
| Target | |
| Fields | |
| Gene name | |
| Protein name | |
| Human gene link | |
| Human Swiss link | |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Recombinant Protein |
| Specificity | |
| Formulation | |
| Clonality | Polyclonal |
| Dilution | IHC 1:200-500 |
| Purification | |
| Concentration | 1mg/mL |
| Storage stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kDa |
| Background | CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta. |
| Function | |
| Subcellular location | Cell membrane |
| Expression |
Additional Images
Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using CD10（EA321）Rabbit pAb diluted at 1:500.
: AO-06-EA321-100
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