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Antibody Product Overview
| ELK.No | ES10142 |
| Product name | PTPRK rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 5796 |
| Human Swiss-Prot | Q15262 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PTPRK |
| Fields | |
| Gene name | PTPRK PTPK |
| Protein name | Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P35822 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 180-260 |
| Specificity | PTPRK Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 158kD |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTP-kappa.,PTM:This protein undergoes proteolytic processing.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 MAM domain.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 4 fibronectin type-III domains.,tissue specificity:High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma., |
| Subcellular location | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. |
| Expression | High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. |
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: AO-06-ES10142-100
: 10 Items
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