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Antibody Product Overview
| ELK.No | ES10570 |
| Product name | CNBP rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 7555 |
| Human Swiss-Prot | P62633 |
| Source | Rabbit |
| Isotype | IgG |
| Target | CNBP |
| Fields | |
| Gene name | CNBP RNF163 ZNF9 |
| Protein name | Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | P53996 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P62634 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 60-140 |
| Specificity | CNBP Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 19kD |
| Background | This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016], |
| Function | disease:Defects in CNBP are the cause of myotonic dystrophy 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). DM2 is an autosomal dominant neurodegenerative disorder characterized by myotonia. DM2 is caused by a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.,function:Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.,similarity:Contains 7 CCHC-type zinc fingers.,tissue specificity:Present in all tissues examined., |
| Subcellular location | Nucleus . Cytoplasm . Endoplasmic reticulum .; [Isoform 1]: Cytoplasm .; [Isoform 2]: Cytoplasm .; [Isoform 4]: Cytoplasm .; [Isoform 5]: Cytoplasm .; [Isoform 6]: Cytoplasm .; [Isoform 8]: Cytoplasm . |
| Expression | Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands. |
Additional Images
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Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES10570-50
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