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Antibody Product Overview
| ELK.No | ES11228 |
| Product name | ARC rabbit pAb |
| Reactivity | Human;Rat;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 23237 |
| Human Swiss-Prot | Q7LC44 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ARC |
| Fields | >>Amphetamine addiction |
| Gene name | ARC KIAA0278 |
| Protein name | Activity-regulated cytoskeleton-associated protein (ARC/ARG3.1) (Activity-regulated gene 3.1 protein homolog) (Arg3.1) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9WV31 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q63053 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 70-150 |
| Specificity | ARC Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 43kD |
| Background | function:Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.,similarity:Belongs to the ARC/ARG3.1 family.,subcellular location:Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.,subunit:Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2., |
| Function | function:Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.,similarity:Belongs to the ARC/ARG3.1 family.,subcellular location:Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.,subunit:Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2., |
| Subcellular location | Extracellular vesicle membrane ; Lipid-anchor . Cell junction, synapse, postsynaptic cell membrane ; Lipid-anchor . Cell junction, synapse . Cell junction, synapse, postsynaptic density . Early endosome membrane . Cell projection, dendrite . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Cell projection, dendritic spine . Cytoplasmic vesicle, secretory vesicle, acrosome . Forms virion-like extracellular vesicles that are released from neurons. Enriched in postsynaptic density of dendritic spines. Targeted to inactive synapses following interaction with CAMK2B in the kinase inactive state. Accumulation at weaker synapses may be required to prevent their undesired enhancement. Associated with the cell cortex of neuronal soma and dendrites (By similarity). Associated with the sperm tail ( |
| Expression | Brain,Forebrain,Uterus, |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11228-100
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