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Antibody Product Overview
| ELK.No | ES11430 |
| Product name | RN135 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 84282 |
| Human Swiss-Prot | Q8IUD6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RN135 |
| Fields | |
| Gene name | RNF135 L13 |
| Protein name | E3 ubiquitin-protein ligase RNF135 (EC 6.3.2.-) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (Riplet) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9CWS1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q5M929 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 81-130 |
| Specificity | RN135 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 47kD |
| Background | ring finger protein 135(RNF135) Homo sapiens The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in RNF135 are the cause of RNF135-related overgrowth syndrome. RNF135-related overgrowth syndrome is characterized by overgrowth, learning disability, dysmorphic features and variable additional features.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger., |
| Subcellular location | Cytoplasm . Cytoplasm, Stress granule . |
| Expression | Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11430-50
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