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Antibody Product Overview
| ELK.No | ES11795 |
| Product name | ABI3 rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51225 |
| Human Swiss-Prot | Q9P2A4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ABI3 |
| Fields | |
| Gene name | ABI3 NESH |
| Protein name | ABI gene family member 3 (New molecule including SH3) (Nesh) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q8BYZ1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 286-336 |
| Specificity | ABI3 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 40kD |
| Background | This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013], |
| Function | function:May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.,similarity:Belongs to the ABI family.,similarity:Contains 1 SH3 domain.,subcellular location:Colocalizes with PAK2 at leading edge of cells.,subunit:May interact with PAK1 and PAK2. Probably interacts with TARSH.,tissue specificity:Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle., |
| Subcellular location | Cytoplasm . Colocalizes with PAK2 at leading edge of cells. |
| Expression | Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle. |
Additional Images
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Western blot analysis of lysates from PC12 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11795-100
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