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Antibody Product Overview
| ELK.No | ES11838 |
| Product name | FAT2 rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | IHC;IF |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 2196 |
| Human Swiss-Prot | Q9NYQ8 |
| Source | Rabbit |
| Isotype | IgG |
| Target | FAT2 |
| Fields | |
| Gene name | FAT2 CDHF8 KIAA0811 MEGF1 |
| Protein name | Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q5F226 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | O88277 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | FAT2 Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 478kD |
| Background | This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008], |
| Function | similarity:Contains 1 laminin G-like domain.,similarity:Contains 2 EGF-like domains.,similarity:Contains 32 cadherin domains., |
| Subcellular location | Cell membrane ; Single-pass type I membrane protein . Cell junction . Golgi apparatus, trans-Golgi network . Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. . |
| Expression | Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level). |
Additional Images
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Tris-EDTA,pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200(4° overnight.3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES11838-50
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