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Antibody Product Overview
| ELK.No | ES11874 |
| Product name | PRKRA rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8575 |
| Human Swiss-Prot | O75569 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PRKRA |
| Fields | |
| Gene name | PRKRA PACT RAX HSD-14 HSD14 |
| Protein name | Interferon-inducible double stranded RNA-dependent protein kinase activator A (PKR-associated protein X) (PKR-associating protein X) (Protein activator of the interferon-induced protein kinase) (Prote |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9WTX2 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | Q4V8C7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | PRKRA Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 34kD |
| Background | This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008], |
| Function | disease:Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:612067]. DYT16 is an early-onset dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT16 patients have progressive, generalized dystonia with axial muscle involvement, oro-mandibular (sardonic smile) and laryngeal dystonia and, in some cases, parkinsonian features.,function:Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor (By similarity). Activates EIF2AK2 in absence of double stranded RNA (dsRNA).,PTM:Phosphorylated on serine.,similarity:Contains 3 DRBM (double-stranded RNA-binding) domains.,subunit:Heterodimer. Interacts with EIF2AK2 through its DRBM domains. Also able to interact with dsRNA., |
| Subcellular location | Cytoplasm, perinuclear region. Cytoplasm. |
| Expression | Brain,Epithelium,Placenta,Testis, |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11874-50
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