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Antibody Product Overview
| ELK.No | ES11987 |
| Product name | GGCT rabbit pAb |
| Reactivity | Human;Mouse |
| Applications | WB;ELISA |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 79017 |
| Human Swiss-Prot | O75223 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GGCT |
| Fields | >>Glutathione metabolism;>>Metabolic pathways |
| Gene name | GGCT C7orf24 CRF21 |
| Protein name | Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21) |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | Q9D7X8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GGCT Polyclonal Antibody detects endogenous levels of protein. |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 20kD |
| Background | The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010], |
| Function | catalytic activity:(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.,function:Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.,induction:By geranylgeraniol.,similarity:Belongs to the gamma-glutamylcyclotransferase family.,subunit:Homodimer., |
| Subcellular location | cytosol,extracellular exosome, |
| Expression | Kidney,Lung,Skeletal muscle,Skin,Urinary bladder, |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES11987-100
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