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Antibody Product Overview
| ELK.No | ES12205 |
| Product name | ZFYV1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 53349 |
| Human Swiss-Prot | Q9HBF4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ZFYV1 |
| Fields | >>Autophagy - animal;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436 |
| Protein name | ZFYV1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 217695 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q810J8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human ZFYV1 AA range: 318-368 |
| Specificity | This antibody detects endogenous levels of ZFYV1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 85kD |
| Observed band (KD) | |
| Background | The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013], |
| Function | sequence caution:Translated as Trp.,similarity:Contains 2 FYVE-type zinc fingers.,subcellular location:Resides predominantly in the cisternal stacks of the Golgi.,subunit:Binds to phosphatidylinositol-3-phosphate (PtdIns3P) through its FYVE-type zinc finger.,tissue specificity:Isoform 1 was expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Both isoforms, 1 and 2 showed a high expression in heart. Isoform 2 is also detected in the testis., |
| Subcellular location | Golgi apparatus, Golgi stack . Golgi apparatus . Endoplasmic reticulum . Lipid droplet . Preautophagosomal structure . Mitochondrion . Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). . |
| Expression | [Isoform 2]: Highly expressed in heart. Also detected in the testis. ; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12205-50
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