Français
English
Antibody Product Overview
| ELK.No | ES12420 |
| Product name | UN93B rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 81622 |
| Human Swiss-Prot | Q9H1C4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | UN93B |
| Fields | |
| Gene name | UNC93B1 UNC93 UNC93B |
| Protein name | UN93B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 54445 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8VCW4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human UN93B AA range: 347-397 |
| Specificity | This antibody detects endogenous levels of UN93B at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 66kD |
| Observed band (KD) | |
| Background | This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014], |
| Function | disease:Defects in UNC93B1 are associated with susceptibility to herpes simplex encephalitis (HSE) [MIM:610551]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. UNC93B-deficient HSE does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies.,online information:UNC93B1 mutation db,similarity:Belongs to the unc-93 family.,tissue specificity:Expressed in heart, heart, and at lower level in kidney. Expressed at low level in other tissues., |
| Subcellular location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. . |
| Expression | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
Additional Images
No image
Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
No image
No image
No image
: AO-06-ES12420-50
: 10 Items
Hurry! only 10 items left in stock.
Use collapsible tabs for more detailed information that will help customers make a purchasing decision.
Ex: Shipping and return policies, size guides, and other common questions.
- Paste the label on a flat surface on the package
- Make sure that both 1D and 2D barcodes are clearly visible
- Ensure that the label is smooth and isn’t creased or wrinkled
- Check for any tears, dents, holes or scratches
- Pack your product tightly, with the right size packaging
- Ensure both barcodes are on a flat surface of the package