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Antibody Product Overview
| ELK.No | ES12437 |
| Product name | UCKL1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 54963 |
| Human Swiss-Prot | Q9NWZ5 |
| Source | Rabbit |
| Isotype | IgG |
| Target | UCKL1 |
| Fields | >>Pyrimidine metabolism;>>Drug metabolism - other enzymes;>>Metabolic pathways;>>Nucleotide metabolism |
| Gene name | UCKL1 URKL1 F538 |
| Protein name | UCKL1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68556 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91YL3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human UCKL1 AA range: 223-273 |
| Specificity | This antibody detects endogenous levels of UCKL1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 60kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014], |
| Function | catalytic activity:ATP + cytidine = ADP + CMP.,catalytic activity:ATP + uridine = ADP + UMP.,function:May contribute to UTP accumulation needed for blast transformation and proliferation.,pathway:Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.,pathway:Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.,PTM:Ubiquitinated by RNF19B; which induces proteasomal degradation.,similarity:Belongs to the uridine kinase family.,subcellular location:EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.,subunit:Interacts with RNF19B and EBV EBNA3.,tissue specificity:Ubiquitous., |
| Subcellular location | Cytoplasm . Nucleus . EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location. |
| Expression | Ubiquitous. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12437-50
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