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Antibody Product Overview
| ELK.No | ES12482 |
| Product name | TXD12 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 51060 |
| Human Swiss-Prot | O95881 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TXD12 |
| Fields | >>Glutathione metabolism;>>Metabolic pathways |
| Gene name | TXNDC12 TLP19 UNQ713/PRO1376 |
| Protein name | TXD12 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 66073 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CQU0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 298370 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q498E0 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TXD12 AA range: 118-168 |
| Specificity | This antibody detects endogenous levels of TXD12 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 19kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012], |
| Function | catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,function:Possesses significant protein thiol-disulfide oxidase activity.,function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed., |
| Subcellular location | Endoplasmic reticulum lumen . |
| Expression | Widely expressed. |
Additional Images
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Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12482-100
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