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Antibody Product Overview
| ELK.No | ES12519 |
| Product name | TTL rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 150465 |
| Human Swiss-Prot | Q8NG68 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TTL |
| Fields | |
| Gene name | TTL |
| Protein name | TTL |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 69737 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P38585 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171572 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9QXJ0 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TTL AA range: 160-210 |
| Specificity | This antibody detects endogenous levels of TTL at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 41kD |
| Observed band (KD) | |
| Background | TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008], |
| Function | catalytic activity:ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.,cofactor:Magnesium.,cofactor:Potassium.,function:Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.,similarity:Belongs to the tubulin--tyrosine ligase family.,similarity:Contains 1 TTL domain.,subunit:Monomer., |
| Subcellular location | |
| Expression |
Additional Images
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Western blot analysis of lysates from THP-1 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12519-50
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