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Antibody Product Overview
| ELK.No | ES12574 |
| Product name | TRI37 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Mulibrey nanism protein) (Tripartite motif-containing protein 37) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4591 |
| Human Swiss-Prot | O94972 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TRI37 |
| Fields | >>Ubiquitin mediated proteolysis |
| Gene name | TRIM37 KIAA0898 MUL POB1 |
| Protein name | TRI37 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68729 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6PCX9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human TRI37 AA range: 315-365 |
| Specificity | This antibody detects endogenous levels of TRI37 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.271% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. [provided by RefSeq, Mar 2016], |
| Function | disease:Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also called muscle-liver-brain-eye nanism. Mulibrey nanism is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 MATH domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Found in vesicles of the peroxisome.,tissue specificity:Ubiquitous., |
| Subcellular location | Cytoplasm, perinuclear region . Peroxisome . Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. . |
| Expression | Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12574-50
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