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Antibody Product Overview
| ELK.No | ES12603 |
| Product name | TPC1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 53373 |
| Human Swiss-Prot | Q9ULQ1 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TPC1 |
| Fields | >>Calcium signaling pathway |
| Gene name | TPCN1 KIAA1169 TPC1 |
| Protein name | TPC1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 252972 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9EQJ0 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 246215 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9WTN5 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TPC1 AA range: 104-154 |
| Specificity | This antibody detects endogenous levels of TPC1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 90kD |
| Observed band (KD) | |
| Background | Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008], |
| Function | domain:Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.,function:May function as one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane.,similarity:Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.,subunit:Dimer .,tissue specificity:Highest expression found in the heart and kidney, and lowest expression found in the spleen., |
| Subcellular location | Lysosome membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . |
| Expression | Highest expression found in the heart and kidney, and lowest expression found in the spleen. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12603-50
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