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Antibody Product Overview
| ELK.No | ES12682 |
| Product name | TLE3 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 7090 |
| Human Swiss-Prot | Q04726 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TLE3 |
| Fields | >>Wnt signaling pathway;>>Notch signaling pathway |
| Gene name | TLE3 KIAA1547 |
| Protein name | TLE3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21887 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q08122 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 84424 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9JIT3 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TLE3 AA range: 257-307 |
| Specificity | This antibody detects endogenous levels of TLE3 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.343% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013], |
| Function | alternative products:Experimental confirmation may be lacking for some isoforms,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1 and TCF7L2 (By similarity). Binds FOXA2.,tissue specificity:Placenta and lung., |
| Subcellular location | Nucleus. |
| Expression | Placenta and lung. |
Additional Images
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Western blot analysis of lysates from THP-1 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12682-100
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