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Antibody Product Overview
| ELK.No | ES12686 |
| Product name | TKNK rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6866 |
| Human Swiss-Prot | Q9UHF0 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TKNK |
| Fields | >>Neuroactive ligand-receptor interaction |
| Gene name | TAC3 NKNB UNQ585/PRO1155 |
| Protein name | TKNK |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 21334 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P55099 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 29191 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P08435 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TKNK AA range: 6-56 |
| Specificity | This antibody detects endogenous levels of TKNK at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 13kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016], |
| Function | developmental stage:In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia.,function:Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.,similarity:Belongs to the tachykinin family., |
| Subcellular location | Secreted. |
| Expression |
Additional Images
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Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES12686-50
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