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Antibody Product Overview
| ELK.No | ES12753 |
| Product name | TFB2M rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 64216 |
| Human Swiss-Prot | Q9H5Q4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | TFB2M |
| Fields | |
| Gene name | TFB2M NS5ATP5 |
| Protein name | TFB2M |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 15278 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3TL26 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 289307 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5U2T7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human TFB2M AA range: 192-242 |
| Specificity | This antibody detects endogenous levels of TFB2M at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 44kD |
| Observed band (KD) | |
| Background | |
| Function | function:S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.,induction:By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators.,similarity:Belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily.,subunit:Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.,tissue specificity:Ubiquitously expressed., |
| Subcellular location | Mitochondrion. |
| Expression | Ubiquitously expressed. |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12753-100
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