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Antibody Product Overview
| ELK.No | ES12955 |
| Product name | SRGP1 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 57522 |
| Human Swiss-Prot | Q7Z6B7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SRGP1 |
| Fields | >>Axon guidance |
| Gene name | SRGAP1 ARHGAP13 KIAA1304 |
| Protein name | SRGP1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 117600 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91Z69 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human SRGP1 AA range: 159-209 |
| Specificity | This antibody detects endogenous levels of SRGP1 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 119kD |
| Observed band (KD) | |
| Background | The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016], |
| Function | function:GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.,sequence caution:Intron retention.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with ROBO1, CDC42 and RHOA.,tissue specificity:Expressed in brain, lung, kidney, and testis., |
| Subcellular location | cytoplasm,cytosol, |
| Expression | Expressed in brain, lung, kidney, and testis. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES12955-100
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