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Antibody Product Overview
| ELK.No | ES13128 |
| Product name | SH3G1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 6455 |
| Human Swiss-Prot | Q99961 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SH3G1 |
| Fields | >>Endocytosis |
| Gene name | SH3GL1 CNSA1 SH3D2B |
| Protein name | SH3G1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20405 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q62419 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 81922 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | O35964 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human SH3G1 AA range: 112-162 |
| Specificity | This antibody detects endogenous levels of SH3G1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 40kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011], |
| Function | disease:In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.,domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes.,function:Implicated in endocytosis. May recruit other proteins to membranes with high curvature.,similarity:Belongs to the endophilin family.,similarity:Contains 1 BAR domain.,similarity:Contains 1 SH3 domain.,subcellular location:Associated with postsynaptic endosomes in hippocampal neurons.,subunit:Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP.,tissue specificity:Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus., |
| Subcellular location | Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Cell projection, podosome . Associated with postsynaptic endosomes in hippocampal neurons. . |
| Expression | Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. |
Additional Images
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Western blot analysis of lysates from Jarkat cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13128-100
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