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Antibody Product Overview
| ELK.No | ES13132 |
| Product name | SGPL1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8879 |
| Human Swiss-Prot | O95470 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SGPL1 |
| Fields | >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway |
| Gene name | SGPL1 KIAA1252 |
| Protein name | SGPL1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 20397 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8R0X7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 286896 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8CHN6 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human SGPL1 AA range: 393-443 |
| Specificity | This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.158% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | |
| Function | catalytic activity:Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.,cofactor:Pyridoxal phosphate.,function:Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.,tissue specificity:Found in liver and kidney., |
| Subcellular location | Endoplasmic reticulum membrane ; Single-pass type III membrane protein ; Cytoplasmic side . |
| Expression | Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343). |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13132-50
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