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GATA-1 (phospho Ser310) rabbit pAb
AO-06-ES1319-100
Antibody Product Overview
| ELK.No | ES1319 |
| Product name | GATA-1 (phospho Ser310) rabbit pAb |
| Reactivity | Human;Mouse;Rat;Monkey |
| Applications | WB;ELISA |
| Other name | GATA1; ERYF1; GF1; Erythroid transcription factor; Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2623 |
| Human Swiss-Prot | P15976 |
| Source | Rabbit |
| Isotype | IgG |
| Target | GATA-1 |
| Fields | |
| Gene name | GATA1 |
| Protein name | Erythroid transcription factor |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 14460 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P17679 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 1.00911e+008 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P43429 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GATA1 around the phosphorylation site of Ser310. AA range:277-326 |
| Specificity | Phospho-GATA-1 (S310) Polyclonal Antibody detects endogenous levels of GATA-1 protein only when phosphorylated at S310. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 43kD |
| Observed band (KD) | |
| Background | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.,disease:Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also called thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. The disease consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.,domain:The two fingers are functionally distinct and cooperate to achie |
| Subcellular location | Nucleus. |
| Expression | Erythrocytes. |
Additional Images
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Western Blot analysis of various cells using Phospho-GATA-1 (S310) Polyclonal Antibody diluted at 1:500 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
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Western blot analysis of lysates from COS7 cells treated with EPO, using GATA1 (Phospho-Ser310) Antibody. The lane on the left is blocked with the phospho peptide.
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: AO-06-ES1319-100
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