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SAMHD1 (phospho-Thr592) rabbit pAb
AO-06-ES13204-100
Antibody Product Overview
| ELK.No | ES13204 |
| Product name | SAMHD1 (phospho-Thr592) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB |
| Other name | SAM domain and HD domain-containing protein 1 (EC 3.1.4.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 25939 |
| Human Swiss-Prot | Q9Y3Z3 |
| Source | Rabbit |
| Isotype | IgG |
| Target | SAMHD1 |
| Fields | >>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection |
| Gene name | SAMHD1 MOP5 |
| Protein name | SAMHD1 (Thr592) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 56045 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60710 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized phosho peptide around human SAMHD1 (Thr592) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat SAMHD1 (phospho-Thr592) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 72kD |
| Background | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010], |
| Function | function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus., |
| Subcellular location | Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. . |
| Expression | Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105). |
Additional Images
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Western Blot analysis of Hela treated or untreated by LPS lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000
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: AO-06-ES13204-100
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