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Antibody Product Overview
| ELK.No | ES13379 |
| Product name | RMI2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 116028 |
| Human Swiss-Prot | Q96E14 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RMI2 |
| Fields | >>Fanconi anemia pathway |
| Gene name | RMI2 C16orf75 |
| Protein name | RMI2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 223970 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3UPE3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RMI2 AA range: 73-123 |
| Specificity | This antibody detects endogenous levels of RMI2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 16kD |
| Observed band (KD) | |
| Background | RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008], |
| Function | function:Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.,PTM:Phosphorylated during mitosis.,similarity:Belongs to the RMI2 family.,similarity:Contains 1 OB DNA-binding domain.,subcellular location:Colocalizes with BLM at nuclear DNA repair foci.,subunit:Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM., |
| Subcellular location | Nucleus . Colocalizes with BLM at nuclear DNA repair foci. |
| Expression |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13379-50
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