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Antibody Product Overview
| ELK.No | ES13391 |
| Product name | RIP rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 84268 |
| Human Swiss-Prot | Q86UA6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RIP |
| Fields | |
| Gene name | RPAIN RIP |
| Protein name | RIP |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 69723 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CWY9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 287463 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q4G2Y1 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human RIP AA range: 117-167 |
| Specificity | This antibody detects endogenous levels of RIP at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 24kD |
| Observed band (KD) | |
| Background | |
| Function | function:Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.,PTM:Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.,similarity:Contains 1 RIP-type zinc finger.,subcellular location:Only nuclear, localizes to PML body.,subunit:Interacts with the RPA1 subunit of RPA complex.,tissue specificity:Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis |
| Subcellular location | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body. |
| Expression | Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen. |
Additional Images
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Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human Breast cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES13391-50
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