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Antibody Product Overview
| ELK.No | ES13393 |
| Product name | RINI rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB;IHC |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6050 |
| Human Swiss-Prot | P13489 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RINI |
| Fields | |
| Gene name | RNH1 PRI RNH |
| Protein name | RINI |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 107702 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q91VI7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 100360501 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P29315 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human RINI AA range: 273-323 |
| Specificity | This antibody detects endogenous levels of RINI at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 51kD |
| Observed band (KD) | |
| Background | Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010], |
| Function | function:Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities.,PTM:At least 30 of the 32 cysteine residues are in the reduced form.,PTM:The N-terminus is blocked.,similarity:Contains 15 LRR (leucine-rich) repeats.,subunit:Forms a tight one-to-one complex with the RNase., |
| Subcellular location | Cytoplasm. |
| Expression |
Additional Images
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Western blot analysis of lysates from PC-12 cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES13393-50
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