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Antibody Product Overview
| ELK.No | ES13465 |
| Product name | RANB3 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Ran-binding protein 3 (RanBP3) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 8498 |
| Human Swiss-Prot | Q9H6Z4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RANB3 |
| Fields | >>Human T-cell leukemia virus 1 infection |
| Gene name | RANBP3 |
| Protein name | RANB3 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 71810 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9CT10 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RANB3 AA range: 421-471 |
| Specificity | This antibody detects endogenous levels of RANB3 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.147% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008], |
| Function | function:Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBD1 domain.,subunit:Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1.,tissue specificity:Widely expressed with high levels in testis and heart., |
| Subcellular location | Cytoplasm . Nucleus . |
| Expression | Widely expressed with high levels in testis and heart. |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13465-50
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