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PZR (phospho-Tyr263) rabbit pAb
AO-06-ES13838-100
Antibody Product Overview
| ELK.No | ES13838 |
| Product name | PZR (phospho-Tyr263) rabbit pAb |
| Reactivity | Human;Mouse;Rat |
| Applications | WB;ELISA;IHC |
| Other name | Myelin protein zero-like protein 1 (Protein zero-related) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9019 |
| Human Swiss-Prot | O95297 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PZR |
| Fields | >>Cell adhesion molecules |
| Gene name | MPZL1 PZR UNQ849/PRO1787 |
| Protein name | PZR (Tyr263) |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68481 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q3TEW6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 360871 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6AYT8 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized phosho peptide around human PZR (Tyr263) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat PZR (phospho-Tyr263) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 30kD |
| Background | |
| Function | domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.,PTM:N-glycosylated.,PTM:Phosphorylated on tyrosine residues up |
| Subcellular location | Membrane ; Single-pass type I membrane protein . |
| Expression | Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. |
Additional Images
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Western blot analysis of lysates from SH-SY5Y cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES13838-100
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