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Antibody Product Overview
| ELK.No | ES14038 |
| Product name | POK17 rabbit pAb |
| Reactivity | Human;Rat;Mouse; |
| Applications | WB |
| Other name | HERV-K_11q22.1 provirus ancestral Pol protein [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)] |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | |
| Human Swiss-Prot | P63136 |
| Source | Rabbit |
| Isotype | IgG |
| Target | POK17 |
| Fields | |
| Gene name | |
| Protein name | POK17 |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human POK17 AA range: 351-401 |
| Specificity | This antibody detects endogenous levels of POK17 at Human |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.229% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | |
| Function | catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,catalytic activity:Endonucleolytic cleavage to 5'-phosphomonoester.,domain:The LPQG and YXDD motifs are catalytically important and conserved among many retroviruses.,function:Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.,miscellaneous:Exact N-terminus of this protein has not been formally described.,miscellaneous:This protein is synthesized as Gag-Pr |
| Subcellular location | |
| Expression |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14038-50
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