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Antibody Product Overview
| ELK.No | ES14043 |
| Product name | PNMT rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5409 |
| Human Swiss-Prot | P11086 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PNMT |
| Fields | >>Tyrosine metabolism;>>Metabolic pathways |
| Gene name | PNMT PENT |
| Protein name | PNMT |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18948 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P40935 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 24661 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P10937 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PNMT AA range: 96-146 |
| Specificity | This antibody detects endogenous levels of PNMT at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 31kD |
| Observed band (KD) | |
| Background | The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012], |
| Function | catalytic activity:S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.,function:Converts noradrenaline to adrenaline.,pathway:Catecholamine biosynthesis; epinephrine biosynthesis; epinephrine from norepinephrine: step 1/1.,similarity:Belongs to the NNMT/PNMT/TEMT family., |
| Subcellular location | cytosol, |
| Expression |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14043-50
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