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Antibody Product Overview
| ELK.No | ES14070 |
| Product name | PLCD4 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 84812 |
| Human Swiss-Prot | Q9BRC7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PLCD4 |
| Fields | >>Inositol phosphate metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Phosphatidylinositol signaling system;>>Thyroid hormone signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Shigellosis |
| Gene name | PLCD4 |
| Protein name | PLCD4 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 18802 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8K3R3 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 140693 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q62711 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PLCD4 AA range: 82-132 |
| Specificity | This antibody detects endogenous levels of PLCD4 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.299% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011], |
| Function | catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain.,domain:The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes.,domain:The PDZ-binding motif mediates the interaction with GRIP1.,domain:The PH domain is not a critical determinant of the membrane localization.,function:Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an |
| Subcellular location | Membrane ; Peripheral membrane protein . Nucleus . Cytoplasm . Endoplasmic reticulum . Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum. |
| Expression | Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. |
Additional Images
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Western blot analysis of lysates from HEK293 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14070-50
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