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Antibody Product Overview
| ELK.No | ES14148 |
| Product name | PGM5 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5239 |
| Human Swiss-Prot | Q15124 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PGM5 |
| Fields | |
| Gene name | PGM5 PGMRP |
| Protein name | PGM5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 226041 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8BZF8 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PGM5 AA range: 357-407 |
| Specificity | This antibody detects endogenous levels of PGM5 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.145% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008], |
| Function | cofactor:Binds 1 magnesium ion per subunit .,function:Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.,similarity:Belongs to the phosphohexose mutase family.,subcellular location:Adherens-type cellular junctions.,subunit:Interacts with cytoskeletal proteins dystrophin and utrophin.,tissue specificity:Expressed in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component., |
| Subcellular location | Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell membrane, sarcolemma . Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments. . |
| Expression | Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level). |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14148-50
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