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Antibody Product Overview
| ELK.No | ES14185 |
| Product name | PDE6G Rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | IHC; ELISA |
| Other name | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (GMP-PDE gamma;EC 3.1.4.35) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 5148 |
| Human Swiss-Prot | P18545 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PDE6G |
| Fields | >>Purine metabolism;>>Metabolic pathways;>>Phototransduction |
| Gene name | PDE6G PDEG |
| Protein name | PDE6G |
| Human gene link | |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | |
| Mouse gene link | |
| Mouse Swiss-Prot | |
| Mouse Swiss link | |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human PDE6G AA range: 10-90 |
| Specificity | This antibody detects endogenous levels of human PDE6G |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | IHC-p 1:50-200, ELISA(peptide)1:5000-20000 |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | |
| Background | This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009], |
| Function | catalytic activity:Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.,function:Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the rod/cone cGMP-PDE gamma subunit family.,subunit:Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain., |
| Subcellular location | plasma membrane,photoreceptor disc membrane, |
| Expression | Human retina,Retina, |
Additional Images
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Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
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: AO-06-ES14185-50
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