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Antibody Product Overview
| ELK.No | ES14254 |
| Product name | PARVA rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 55742 |
| Human Swiss-Prot | Q9NVD7 |
| Source | Rabbit |
| Isotype | IgG |
| Target | PARVA |
| Fields | >>Focal adhesion |
| Gene name | PARVA MXRA2 |
| Protein name | PARVA |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 57342 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9EPC1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 57341 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9HB97 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human PARVA AA range: 178-228 |
| Specificity | This antibody detects endogenous levels of PARVA at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 41kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010], |
| Function | function:Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.,similarity:Belongs to the parvin family.,similarity:Contains 2 CH (calponin-homology) domains.,subcellular location:Constituent of focal adhesions.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with CDGAP.,tissue specificity:Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver., |
| Subcellular location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line . Constituent of focal adhesions. Associates with the actin cytoskeleton. |
| Expression | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14254-50
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