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Antibody Product Overview
| ELK.No | ES14432 |
| Product name | NUDT5 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 11164 |
| Human Swiss-Prot | Q9UKK9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NUDT5 |
| Fields | >>Purine metabolism;>>Metabolic pathways |
| Gene name | NUDT5 HSPC115 |
| Protein name | NUDT5 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 53893 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9JKX6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 361274 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q6AY63 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human NUDT5 AA range: 95-145 |
| Specificity | This antibody detects endogenous levels of NUDT5 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 24kD |
| Observed band (KD) | |
| Background | This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013], |
| Function | catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,catalytic activity:ADP-sugar + H(2)O = AMP + alpha-D-aldose 5-phosphate.,cofactor:Magnesium.,function:Hydrolyzes with similar activities ADP-ribose, ADP-mannose, and ADP-glucose. Can also hydrolyze other nucleotide sugars with low activity.,similarity:Belongs to the Nudix hydrolase family.,subunit:Homodimer.,tissue specificity:Widely expressed. Most abundant in liver., |
| Subcellular location | Nucleus . |
| Expression | Widely expressed. Most abundant in liver. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14432-50
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