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Antibody Product Overview
| ELK.No | ES13314 |
| Product name | RUBIC rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Run domain Beclin-1 interacting and cystein-rich containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 9711 |
| Human Swiss-Prot | Q92622 |
| Source | Rabbit |
| Isotype | IgG |
| Target | RUBIC |
| Fields | >>Autophagy - animal |
| Gene name | KIAA0226 |
| Protein name | RUBIC |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 100502698 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q80U62 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human RUBIC AA range: 868-918 |
| Specificity | This antibody detects endogenous levels of RUBIC at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.290% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014], |
| Function | similarity:Contains 1 RUN domain., |
| Subcellular location | Late endosome . Lysosome . Early endosome . Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus. |
| Expression | Blood,Bone marrow,Heart,Kidney, |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13314-100
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