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Antibody Product Overview
| ELK.No | ES13355 |
| Product name | ROM1 rabbit pAb |
| Reactivity | Human; Mouse;Rat;C. parvum |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 6094 |
| Human Swiss-Prot | Q03395 |
| Source | Rabbit |
| Isotype | IgG |
| Target | ROM1 |
| Fields | |
| Gene name | ROM1 TSPAN23 |
| Protein name | ROM1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 19881 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P32958 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 309201 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5PPM7 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human ROM1 AA range: 163-213 |
| Specificity | This antibody detects endogenous levels of ROM1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 39kD |
| Observed band (KD) | |
| Background | This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008], |
| Function | disease:Defects in ROM1 may cause retinitis pigmentosa (RP) [MIM:268000]; when associated with defects in PRPH2.,function:May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the PRPH2/ROM1 family.,subunit:Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could associate with this complex in rods.,tissue specificity:Retina (photoreceptor). In rim region of ROS (rod outer segment) disks., |
| Subcellular location | Photoreceptor inner segment membrane ; Multi-pass membrane protein . Photoreceptor outer segment membrane ; Multi-pass membrane protein . |
| Expression | Retina photoreceptors (at protein level) (PubMed:1610568, PubMed:8504299). In rim region of ROS disks (PubMed:1610568). |
Additional Images
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Western blot analysis of lysates from CACO2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES13355-50
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