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Antibody Product Overview
| ELK.No | ES14467 |
| Product name | NOSTN rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 115677 |
| Human Swiss-Prot | Q8IVI9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NOSTN |
| Fields | |
| Gene name | NOSTRIN |
| Protein name | NOSTN |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 329416 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6WKZ7 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 311111 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q5I0D6 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human NOSTN AA range: 309-359 |
| Specificity | This antibody detects endogenous levels of NOSTN at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 56kD |
| Observed band (KD) | |
| Background | Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004], |
| Function | domain:The FCH domain is necessary for membrane targeting.,domain:The SH3 domain mediates interaction with NOS3, DNM2 and WASL.,function:Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.,similarity:Contains 1 FCH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Enriched in selected actin structures.,subunit:Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.,tissue specificity:Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level)., |
| Subcellular location | [Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus . |
| Expression | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level). |
Additional Images
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Western blot analysis of lysates from MDA-MB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14467-100
: 10 Items
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