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Antibody Product Overview
| ELK.No | ES14494 |
| Product name | NH2L1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 4809 |
| Human Swiss-Prot | P55769 |
| Source | Rabbit |
| Isotype | IgG |
| Target | NH2L1 |
| Fields | >>Ribosome biogenesis in eukaryotes;>>Spliceosome |
| Gene name | NHP2L1 |
| Protein name | NH2L1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 100862468 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q9D0T1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 100359574 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P55770 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human NH2L1 AA range: 33-83 |
| Specificity | This antibody detects endogenous levels of NH2L1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 14kD |
| Observed band (KD) | |
| Background | Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008], |
| Function | function:Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.,similarity:Belongs to the ribosomal protein L7Ae family.,subcellular location:Concentrated in the dense fibrillar component of the nucleolus.,subunit:Interacts with RAD17.,tissue specificity:Ubiquitous., |
| Subcellular location | Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus. . |
| Expression | Ubiquitous. |
Additional Images
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Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14494-100
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