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Antibody Product Overview
| ELK.No | ES14955 |
| Product name | MFN1 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 55669 |
| Human Swiss-Prot | Q8IWA4 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MFN1 |
| Fields | >>Mitophagy - animal;>>NOD-like receptor signaling pathway;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases |
| Gene name | MFN1 |
| Protein name | MFN1 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 67414 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q811U4 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 192647 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8R4Z9 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human MFN1 AA range: 163-213 |
| Specificity | This antibody detects endogenous levels of MFN1 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.12% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 85kD |
| Background | The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.,similarity:Belongs to the mitofusin family.,subunit:Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex.,tissue specificity:Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers., |
| Subcellular location | Mitochondrion outer membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm . |
| Expression | Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411). |
Additional Images
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Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES14955-50
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