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Antibody Product Overview
| ELK.No | ES15002 |
| Product name | MCLN2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | Mucolipin-2 |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 255231 |
| Human Swiss-Prot | Q8IZK6 |
| Source | Rabbit |
| Isotype | IgG |
| Target | MCLN2 |
| Fields | >>Calcium signaling pathway |
| Gene name | MCOLN2 |
| Protein name | MCLN2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68279 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8K595 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human MCLN2 AA range: 328-378 |
| Specificity | This antibody detects endogenous levels of MCLN2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.134% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 60kD |
| Background | Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009], |
| Function | sequence caution:Translated as Trp.,similarity:Belongs to the transient receptor family. Polycystin subfamily., |
| Subcellular location | Cell membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Localizes to recycling endosomes in activated macrophages and microglia. . |
| Expression | Uterus, |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15002-100
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