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Antibody Product Overview
| ELK.No | ES15076 |
| Product name | LX15B rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 247 |
| Human Swiss-Prot | O15296 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LX15B |
| Fields | >>Arachidonic acid metabolism;>>Metabolic pathways;>>Serotonergic synapse |
| Gene name | ALOX15B |
| Protein name | LX15B |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 11688 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | O35936 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 266604 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q8K4F2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human LX15B AA range: 576-626 |
| Specificity | This antibody detects endogenous levels of LX15B at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 74kD |
| Observed band (KD) | |
| Background | This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,tissue specificity:Expressed in hair, prostate, lung and cornea., |
| Subcellular location | [Isoform A]: Nucleus . Other isoforms are excluded from the nucleus. .; Cytoplasm, cytosol . Cell membrane . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, focal adhesion . Predominantly cytosolic; becomes enriched at membranes upon calcium binding. . |
| Expression | Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea. |
Additional Images
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Western blot analysis of lysates from MCF-7 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15076-50
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