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Antibody Product Overview
| ELK.No | ES15085 |
| Product name | LTC4S rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 4056 |
| Human Swiss-Prot | Q16873 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LTC4S |
| Fields | >>Arachidonic acid metabolism;>>Metabolic pathways |
| Gene name | LTC4S |
| Protein name | LTC4S |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 17001 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q60860 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 114097 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q925U2 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human LTC4S AA range: 29-79 |
| Specificity | This antibody detects endogenous levels of LTC4S at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 17kD |
| Observed band (KD) | |
| Background | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008], |
| Function | catalytic activity:Leukotriene C(4) = leukotriene A(4) + glutathione.,disease:Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.,function:Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer. Interacts with ALOX5AP and ALOX5.,tissue specificity:Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets., |
| Subcellular location | Nucleus outer membrane ; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein. Nucleus membrane ; Multi-pass membrane protein. |
| Expression | Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. |
Additional Images
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Western blot analysis of lysates from 293T cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15085-50
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