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Antibody Product Overview
| ELK.No | ES15125 |
| Product name | LR16A rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB;IHC |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 55604 |
| Human Swiss-Prot | Q5VZK9 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LR16A |
| Fields | |
| Gene name | LRRC16A CARMIL LRRC16 |
| Protein name | LR16A |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 68732 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q6EDY6 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human LR16A AA range: 853-903 |
| Specificity | This antibody detects endogenous levels of LR16A at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 151kD |
| Observed band (KD) | |
| Background | |
| Function | function:Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization.,similarity:Belongs to the CARMIL family.,similarity:Contains 11 LRR (leucine-rich) repeats.,subcellular location:Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers.,subunit:Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation.,tissue specificity:Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney., |
| Subcellular location | Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium . Found on macropinosomes (PubMed:19846667). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667). . |
| Expression | Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
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: AO-06-ES15125-100
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