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Antibody Product Overview
| ELK.No | ES15164 |
| Product name | LFTY2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 7044 |
| Human Swiss-Prot | O00292 |
| Source | Rabbit |
| Isotype | IgG |
| Target | LFTY2 |
| Fields | >>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells |
| Gene name | LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024 |
| Protein name | LFTY2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 320202 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P57785 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human LFTY2 AA range: 205-255 |
| Specificity | This antibody detects endogenous levels of LFTY2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 40kD |
| Observed band (KD) | |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016], |
| Function | developmental stage:Transiently expressed before and during menstrual bleeding.,disease:Defects in LEFTY2 are the cause of left-right axis malformations (L-R axis malformation) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.,function:Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,sequence caution:Authors have revised their sequence, but have not submitted the revised DNA sequence.,similarity:Belongs to the TGF-beta family.,tissue specificity:Mesenchymal cells of the endometrial stroma., |
| Subcellular location | Secreted. |
| Expression | Mesenchymal cells of the endometrial stroma. |
Additional Images
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Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15164-100
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