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Antibody Product Overview
| ELK.No | ES15305 |
| Product name | KIF5C rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 3800 |
| Human Swiss-Prot | O60282 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KIF5C |
| Fields | >>Endocytosis;>>Dopaminergic synapse;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Salmonella infection;>>Non-small cell lung cancer |
| Gene name | KIF5C KIAA0531 NKHC2 |
| Protein name | KIF5C |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 16574 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P28738 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | P56536 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human KIF5C AA range: 119-169 |
| Specificity | This antibody detects endogenous levels of KIF5C at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.247% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015], |
| Function | domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3.,tissue specificity:Highest expression in brain, prostate and testis, and moderate expression in kidney |
| Subcellular location | Cytoplasm, cytoskeleton . Cell projection, dendrite . Abundant in distal regions of dendrites. . |
| Expression | Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary. |
Additional Images
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Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15305-100
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