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Antibody Product Overview
| ELK.No | ES15352 |
| Product name | KCC2G rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 818 |
| Human Swiss-Prot | Q13555 |
| Source | Rabbit |
| Isotype | IgG |
| Target | KCC2G |
| Fields | >>ErbB signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>HIF-1 signaling pathway;>>Oocyte meiosis;>>Necroptosis;>>Adrenergic signaling in cardiomyocytes;>>Wnt signaling pathway;>>Axon guidance;>>Circadian entrainment;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Cholinergic synapse;>>Dopaminergic synapse;>>Olfactory transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Glucagon signaling pathway;>>Aldosterone synthesis and secretion;>>Cushing syndrome;>>Gastric acid secretion;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Amphetamine addiction;>>Tuberculosis;>>Pathways in cancer;>>Proteoglycans in cancer;>>Glioma;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis |
| Gene name | CAMK2G CAMK CAMK-II CAMKG |
| Protein name | KCC2G |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 12325 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q923T9 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 171140 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | P11730 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human KCC2G AA range: 490-540 |
| Specificity | This antibody detects endogenous levels of KCC2G at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 61kD |
| Observed band (KD) | |
| Background | The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011], |
| Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits., |
| Subcellular location | Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . |
| Expression | Expressed in skeletal muscle. |
Additional Images
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Western blot analysis of lysates from SW480 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15352-50
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