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Antibody Product Overview
| ELK.No | ES15440 |
| Product name | IPO13 rabbit pAb |
| Reactivity | Human; Mouse;Rat |
| Applications | WB |
| Other name | Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13) |
| Size | 50μL |
| Unit price ($) | 148 |
| Human gene ID | 9670 |
| Human Swiss-Prot | O94829 |
| Source | Rabbit |
| Isotype | IgG |
| Target | IPO13 |
| Fields | >>Nucleocytoplasmic transport |
| Gene name | IPO13 KIAA0724 RANBP13 |
| Protein name | IPO13 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 230673 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | Q8K0C1 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | 116458 |
| Rat gene link | View Rat Gene |
| Rat Swiss-Prot | Q9JM04 |
| Rat Swiss link | View Rat Swiss-Prot |
| Immunogen | Synthesized peptide derived from human IPO13 AA range: 484-534 |
| Specificity | This antibody detects endogenous levels of IPO13 at Human/Mouse/Rat |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.263% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1:500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | |
| Observed band (KD) | 105kD |
| Background | This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009], |
| Function | function:Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox |
| Subcellular location | Cytoplasm. Nucleus. |
| Expression | Expressed in fetal brain, heart, intestine and kidney. |
Additional Images
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Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15440-50
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