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Antibody Product Overview
| ELK.No | ES15697 |
| Product name | HME2 rabbit pAb |
| Reactivity | Human; Mouse |
| Applications | WB |
| Other name | |
| Size | 100μL |
| Unit price ($) | 248 |
| Human gene ID | 2020 |
| Human Swiss-Prot | P19622 |
| Source | Rabbit |
| Isotype | IgG |
| Target | HME2 |
| Fields | |
| Gene name | EN2 |
| Protein name | HME2 |
| Human gene link | View Human Gene |
| Human Swiss link | View Human Swiss-Prot |
| Mouse gene ID | 13799 |
| Mouse gene link | View Mouse Gene |
| Mouse Swiss-Prot | P09066 |
| Mouse Swiss link | View Mouse Swiss-Prot |
| Rat gene ID | |
| Rat gene link | |
| Rat Swiss-Prot | |
| Rat Swiss link | |
| Immunogen | Synthesized peptide derived from human HME2 AA range: 225-275 |
| Specificity | This antibody detects endogenous levels of HME2 at Human/Mouse |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Dilution | WB 1：500-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage stability | -20°C/1 year |
| Molecular Weight (Da) | 37kD |
| Observed band (KD) | |
| Background | Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008], |
| Function | disease:Genetic variations in EN2 may be associated with susceptibility to autism type 10 (AUTS10) [MIM:611016]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical and ritualized patterns of interests and behavior.,similarity:Belongs to the engrailed homeobox family.,similarity:Contains 1 homeobox DNA-binding domain., |
| Subcellular location | Nucleus. |
| Expression |
Additional Images
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Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°over night
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: AO-06-ES15697-100
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